ZimVie Debuts Biotivity A/C Plus Membrane

ZimVie Inc. has launched the Biotivity A/C Plus Membrane, a growth factor rich membrane used for site coverage and protection from the oral environment in a variety of dental applications. The membrane is now available in the United States.
 
Dental bone grafting procedures, along with protective barrier membranes, are used to repair or reconstruct the jaw and to provide a foundation for dental implant placement. This launch broadens ZimVie’s presence in the dental biomaterials market, expanding into the large growth factor segment. ZimVie’s Biotivity A/C Plus Membrane is a barrier membrane containing a variety of growth factors, cytokines, chemokines, and hyaluronic acid shown to facilitate wound healing.^1-3
 
“We remain focused on bringing new products to market to meet customer needs and ensure their teams have the best solutions at their disposal,” said Indraneel Kanaglekar, senior vice president and president of ZimVie Dental. “Biotivity’s triple-layer structure is thicker than conventional A/C membranes and may contribute to enhanced conformability and growth factor content.”^1,2,4

Biotivity A/C Plus Membrane is a growth factor-charged membrane derived from human placental tissue. Consisting of the amnion, intermediate, and chorion layers, Biotivity A/C Plus is minimally manipulated using proprietary processing that preserves natural mechanical properties, elasticity, growth factors, cytokines, and other biological enhancers.^5,6 The product has been sterilized using the Excellion Process, and terminally sterilized with Electron-Beam irradiation. Unlike other A/C membranes available on the market Biotivity A/C Plus is not treated with antibiotics during the processing.^5,7
 
ZimVie develops, manufactures, and delivers products and solutions to treat a wide range of spine pathologies and support dental tooth replacement and restoration procedures. The company was founded in March 2022 as an independent, publicly traded spin-off of Zimmer Biomet’s Dental and Spine business units to breathe new life, dedicated energy, and strategic focus to its brands and products. From its headquarters in Westminster, Colo., and additional facilities around the globe, the company serves customers in more than 70 countries worldwide. 

References
¹ Malak T.M. et al. Placenta (1993) 14:385-406.
² Roy A., Griffiths S. J Tissue Eng Regen Med (2020) 14:1126-1135.
³ Bryant-Greenwood G.D. Placenta (1998) 19:1-11.
⁴ Hieber A.D. et al. Placenta (1997) 18:301-312.
⁵ Data on file with manufacturer.
⁶ Koizumi N. et al. Curr Eye Res (2000) 20:173-177.
⁷ Biotivity A/C Plus Membrane IFU Rev. 03.